非小细胞肺癌中单器官转移和局部肿瘤情况对

点击下方，收听SCI天天读SCISingleorganmetastaticdiseaseandlocaldiseasestatus,prognosticfactorsforoverallsurvivalinstageIVnon-smallcelllungcancer:Resultsfromapopulation-basedstudy.PURPOSEToanalysetheprognosticimpactonoverallsurvival(OS)ofsingleversusmultipleorganmetastases,organaffected,andlocaldiseasestatusinapopulationbasedstageIVnon-smallcelllungcancer(NSCLC)cohort.METHODSInthisobservationalstudy,datawereanalysedofallhistologicallyconfirmedstageIVNSCLCpatientsdiagnosedbetween1Januaryand31DecemberregisteredintheNetherlandsCancerRegistry.Locationofmetastasesbeforetreatmentwasregistered.Multivariablesurvivalanalyses[age,gender,histology,M-status,localdiseasestatus,numberofinvolvedorgans,actualorganaffected]wereperformedforallpatientsandforan18fluorodeoxyglucose-positronemissiontomography(18FDG-PET)-stagedsubgroup.RESULTS11,patientswereselected:60%male,meanage65years,73%adenocarcinoma.MedianOSfor1(N=),2(N=),and?3(N=)metastaticallyaffectedorganswas6.7,4.3,2.8months,respectively(p0.).Hazardratio(HR)for2versus1organ(s)was1.33(p0.),for?3versus1organ(s)1.91(p0.).Resultswereconfirmedinthe18FDG-PET-stagedcohort(N=):patientswithsingleorganversus2and?3organmetastaseshadhigherOS(8.6,5.7,3.8months,HR1.40and2.17,respectively,p0.).Insingleorganmetastases,OSforlowversushighTN-statuswas8.5versus6.5months[HR1.40(p0.)].18FDG-PET-stagedsingleorganmetastasespatientswithlowTN-statushadasuperiorOSthanthosewithhighTN-status(11.6versus8.2months,HR1.62,p0.).CONCLUSIONPatientswithsingleorganmetastasesstageIVNSCLChaveafavourableprognosis,especiallyin







































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